Glucosamine Forte - Research Brief
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I Recommended Use |
I Clinical Trials |
I Research Brief |
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Indication: impaired joint mobility, sprain of ligaments, physical overload, inflammatory and degenerative joint damage, salt deposits in the joints, sports trauma prophylaxis. Main Actions: helps to rehabilitate the joint cartilage, stimulates the production of synovial fluid, helps to dissolve salt deposits in the joints, strengthens the ligaments, improves circulation and nourishes the muscular tissues, helps to restore the mucous lining of the stomach. Ingredients:(per 1 capsule): Glucosamine Hydrochloride – 300.0 mg, Chondroitin Sulfate – 150.0 mg, proprietary blend – 139.0 mg, Devil’s claw (Harpagophytum procumbens) root powder, shark cartilage extract.
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Glucosamine Forte - Research Brief:
Moveable (synovial) joints in the skeletal system are characterized by the presence of a cushioning layer of cartilage on the ends of where the bones meet. This cartilage layer reduces the friction between the bones and allows for easier movement of the joint.
Cartilage is a tough but resilient connective tissue that is constantly rebuilding to compensate for the mechanical stresses put on the joint. In addition, the joint is surrounded by tough layers of connective tissue that hold the joint together and also secrete a fluid that bathes the cartilage pads to reduce friction further. However, accumulated wear and tear on the joints results in the breakdown and thinning of the cartilage, causing pain, inflammation, and loss of motion (osteoarthritis).
Cartilage is composed of molecules known as proteoglycans, which are deposited within a matrix of collagen fibers. This complex traps water and helps give cartilage its flexibility, resiliency, and resistance to compression.
Both chondroitin sulfate and glucosamine are essential for proteoglycan synthesis.
Chondroitin sulfate is an important structural component of cartilage and provides much of its resistance to compression.
Glucosamine is essential for the formation of the cartilage, ligaments, synovial fluid, connective tissues and bones.
Glucosamine hydrochloride demonstrates more stability, purity, and higher concentration when compared to glucosamine sulfate. During the preparation of glucosamine sulfate, sodium and potassium are added, and about 83 percent of glucosamine hydrochloride is actual glucosamine while only about 63 percent of glucosamine sulfate is actual glucosamine. Therefore, one gets more glucosamine per capsule form glucosamine hydrochloride than from glucosamine sulfate.
A significant synergistic effect has been reported recently using combined glucosamine hydrochloride and chondroitin sulfate in an experimental study. The combination was more effective than either substance alone in inhibiting progression of degenerative cartilage lesions.